Thalamic Deep Brain Stimulation for Tourette Syndrome
نویسندگان
چکیده
L. Ackermansa, I. Neunerb, Y. Temela,c, A. Duitsd,e, J. Kuhnf and V. Visser-Vandewalleg,∗ Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Science, Maastricht, The Netherlands Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands School of Mental Health and Neuroscience (MHENS), Mondriaan Zorggroep, Maastricht, The Netherlands Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
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Deep Brain Stimulation of the H Fields of Forel Alleviates Tics in Tourette Syndrome
The current rationale for target selection in Tourette syndrome revolves around the notion of cortico-basal ganglia circuit involvement in the pathophysiology of the disease. However, despite extensive research, the ideal target for deep brain stimulation (DBS) is still under debate, with many structures being neglected and underexplored. Based on clinical observations and taking into account t...
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BACKGROUND/AIMS Tourette syndrome (TS) is a complex neurological disorder manifested chiefly by motor and phonic tics and a variety of behavioral comorbidities, including attention disorder, obsessive-compulsive disorder and impulse control problems. Surgical treatment is increasingly considered when tics become troublesome or even disabling or self-injurious despite optimal medical therapy. In...
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BACKGROUND Deep brain stimulation (DBS) remains an experimental but promising treatment for patients with severe refractory Gilles de la Tourette syndrome (TS). Controversial issues include the selection of patients (age and clinical presentation), the choice of brain targets to obtain optimal patient-specific outcomes, and the risk of surgery- and stimulation-related serious adverse events. ...
متن کاملReview CALL FOR PAPERS Neurobiology of Deep Brain Stimulation Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation
Israelashvili M, Loewenstern Y, Bar-Gad I. Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation. J Neurophysiol 114: 6–20, 2015. First published April 29, 2015; doi:10.1152/jn.00277.2015.— Tourette syndrome (TS) is a common childhood-onset disorder characterized by motor and vocal tics that are typically accompanied by a multitude of comorbid symptoms....
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OBJECTIVE Tourette's syndrome (TS) is defined by 1 year of persistent motor and vocal tics. Often, the tics are refractory to conventional pharmacologic and psychobehavioral interventions. In these patients, deep brain stimulation (DBS) may be an appropriate intervention. This paper reviews different DBS targets in TS, discusses existing evidence on the efficacy of DBS in TS, highlights adverse...
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BACKGROUND Gilles de la Tourette Syndrome (GTS) is a complex neuropsychiatric disorder, characterized by chronic motor and vocal tics, associated in 50-90% of cases with psychiatric comorbidities. Patients with moderate and severe clinical picture are treated with psychotherapy and pharmacological therapy. Deep brain stimulation (DBS) is reserved for pharmacological refractory GTS patients. As ...
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